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Unravel the Science of Ongoing VOC Damage in Sickle Cell Disease

Sickle cell disease (SCD) is a complex genetic disorder that goes beyond red blood cells and early on progresses to a chronic vascular disease.1 Silent ongoing vaso-occlusion that drives the chronic nature of the disease is caused by multicellular adhesion among endothelial and blood cells, and is the result of upregulation of specific adhesion mediators.2,3 Vaso-occlusion can culminate in vaso-occlusive crises (VOCs)—the clinical hallmark of sickle cell disease. VOCs are associated with decreased quality of life and increased risk of organ damage and death.4-6


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